![]() ![]() All data were analysed in a secure, anonymised database physically separated from the main production server. All methods were performed in accordance with relevant guidelines and regulations. The requirement of informed consent was waived. The study was reviewed by an Institutional Review Board (CAAE 459786.5461) and deemed exempt from IRB oversight (Instituto de Ensino e Pesquisa, IEP, Hospital Sírio Libanês). Moreover, no or incomplete vaccination would be independently associated with persistence of symptoms after hospital discharge. We hypothesised that patients with no or incomplete vaccination would present at least one symptom compared to patients with complete vaccination (at least two doses for all vaccines but ≥ 1 dose for the Janssen™ vaccine, as described by others 10). ![]() In the current study, we systematically evaluated several long COVID symptoms 90 days after hospital discharge in consecutive patients, according to vaccination status. Therefore, it is unclear whether vaccination status influences the magnitude of long COVID symptoms in patients with more severe disease who frequently require more intensive support and are more susceptible to long-term complications. Recent reports suggest that vaccination can reduce long COVID in patients who do not need hospitalisation 7, 8, 9, 10. From 2021, progressive implementation of effective vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has mitigated the risk of complications, including hospitalisations and mortality 5, 6. The commonly reported residual symptoms include fatigue, dyspnoea, and chest pain, among others (collectively described as post-acute COVID-19 syndrome or long COVID) 1, 2, 3, 4. In conclusion, even in patients with severe COVID-19, vaccination mitigates the probability of long COVID symptoms.Ĭoronavirus disease 2019 (COVID-19) promotes a significant burden of symptoms in the subacute and long term post infection 1. ![]() After adjusting for confounders, no or incomplete vaccination (odds ratio 1.819 95% confidence interval 1.175–2.815), female sex (OR 2.435 95% CI 1.575–3.764) and ICU admission during hospitalisation (OR 1.697 95% CI 1.062–2.712) were independently associated with ≥ 1 symptom 90 days after hospital discharge. Ninety days after hospital discharge, patients with no or incomplete vaccination presented a higher frequency of symptoms (≥ 1) than patients with complete vaccination (40 vs. Data during hospitalisation revealed that the no or incomplete vaccination group required more admissions to the intensive care unit (ICU), used more corticosteroids, and had higher rates of pulmonary embolism or deep venous thrombosis than the complete vaccination group. Compared with patients with complete vaccination (n = 185) before infection or hospitalisation, those with no or incomplete vaccination (n = 227) were younger and had a lower frequency of several comorbidities. Here, we evaluated 412 patients (age: 60 ± 16 years, 65% males) consecutively admitted to two Hospitals in Brazil due to confirmed coronavirus disease 2019 (COVID-19). The available evidence is limited to outpatients with mild disease. This powerful software package helps you handle highly complex data manipulation and analysis with a simple, drag-and-drop interface and user-friendly instructions.Effective vaccination against coronavirus mitigates the risk of hospitalisation and mortality however, it is unclear whether vaccination status influences long COVID symptoms in patients who require hospitalisation. With SPSS, you can manage the entire statistical analysis process-from data collection to analysis to reporting-allowing you to make better decisions and improve performance. SPSS is one of the world’s leading statistical packages for in-depth research. ![]()
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